Molecular Biology and Biochemistry: Biofunctionalization

Target: Development of biofunctionalized nanoparticles for biomedical applications.

Description: Development of selective markers based on magnetic nanoparticles to be used as contrast agents for early diagnosis of Alzheimer´s disease by RMI. Labeling of human neural precursor cells (hNPCs) with magnetic nanoparticles for in vivo cell tracking in cell replacement therapies against neurodegenerative diseases (i.e. Parkinson disease). Development of nanomarkers for early tumor diagnosis and therapy. Synthesis and characterization of biofunctionalized nanostructures for MRI and hyperthermia.

 Techniques:

-Cell viability and cytoxicicty assays.

-Synthesis of nanoconjugates.

-Cell transplantation.

-Animal models of neurodegenerative diseases.

-Immunocytochemistry.

-Histology.

Infrastructure:

-Laboratory of biochemistry.

-Cell culture lab.

-Optical fluorescence microscopy.

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