Advanced biomedical imaging technologies

Neuroimaging Biomarkers in Aging and Dementia. Application of volumetric techniques (Voxel-Based Morphometry, VBM) at different stages of neurodegenerative diseases.

Quality Control in High Field Scanners. Measurement of the stability parameters (SNR and SFNR) on a phantom spectroscopy MRS and fMRI sequences (EPI).

Neuroimaging Correlation with Clinical Scores. Traditional clinical scales, used by clinicians to appraise the pathological evolution, are not neuroimaging facts related to.

In this lane we are assessing the link between clinical scores and brain neuroimaging.

Cerebral Perfusion without Exogenous contrast. Study of relationship between level of hematocrit (HCT) and quantification in sequences of Arterial Spin Labeling. Concluding that the HCT% is a necessary variable in any statistical study of ASL.

Other specific result has been the optimization technique for high resolution ASL.

Functional Connectivity in Olfactory Function. Functional connectivity biomarker smell as prodromal Alzheimer states. We did experiments with olfactory stimuli in healthy subjects with a sequence of simultaneous acquisition of rCBF and BOLD with two labeling techniques: PASL and PCASL. We have demonstrated the feasibility of using this technique to study simultaneously medial temporal areas that may represent a breakthrough in the objective evaluation of smell and its use as a biomarker of neurodegenerative diseases.

We also studied the functional connectivity at rest:  The resting functional connectivity has been studied in a test-retest experiment cognitive training in 20 healthy girls divided into two groups. Found localized increases connectivity in areas related to training in the trained group compared to no training. These tests can improve methods of functional connectivity analysis applied to the study neurodegenarativas diseases.

Simultaneous EEG-fMRI Recording. We have also carried out simultaneous electroencephalography registration:

It proposes using EEG-fMRI simultaneous recording in the study of smell in order to combine the information from both technical and statistically significant results.

We found a statistically significant increase in EEG beta power in frontal areas after the appearance of olfactory stimulation. This increase has been used to modulate the hemodynamic response to the GLM analysis modeled the fMRI images.

It has been shown that the use of the information extracted from EEG analysis improves the statistical results fMRI image analysis. Showing activations located in areas relevant olfactory stimuli with greater statistical power.

Connectivity in Neurological and Psychiatric Disorders. We also studied the connectivity in two patients with epilepsy Fixation-off simultálneo study finding that EEG and fMRI and the combined use of data from the analysis of the two techniques help improve the diagnosis in these patients. Therefore demonstrates the technical feasibility of using the technique of EEG-fMRI simultaneous recording in preclinical studies of neurological diseases.

Functional and Structural Connectivity. Characterizing the network topology functional and anatomical. We have built functional and anatomical networks derived from rs-fMRI and DTI respectively. We used to do an allotment of 90 cortical regions in a sample of 10 young subjects in two acquisitions. A comprehensive analysis by complex network theory shows that networks are differing in organization and efficiency.

Laboratories:

  • Neuroimaging
  • Cognitive and Computational Neuroscience
  • Cajal Cortical Circuits
  • Biological Networks
  • Advanced Applied Mathematics to Biological Systems
  • Molecular Biology and Biochemistry: Bionfucntionalization
  • Bioelectromagnetism
  • Data Mining and Simulation

Productivity

 Contact: Juan Antonio Hernández Tamames

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